Pharmaceutical composition for oral administration of a pyrazol-3-carboxamide derivative

摘要

Disclosed is a liquid or semi-solid pharmaceutical composition comprising a pyrazol-3-carboxamide derivative dissolved in a mixture containing one or more lipid solvents, and a non-ionic hydrophilic surfactant. The said derivative is chosen from N-piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-pyrazole-3-carboxamide and N-piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-pyrazole-3-carboxamide. The composition is self-emulsionable or self-microemulsionable in an aqueous medium and allows for improved bioavailability in the fasted state.