| 摘要 |
Disclosed is an oral care product comprising one or more dosages of a peptide present in an amount effective for oral care, wherein a single dosage is less than 100mg of the peptide, and wherein the peptide is the formula: P1-L-P1 wherein: P1 is a peptide which is capable of binding a metal ion; L is a chemical group which connects the two P1 peptides through their C-terminal amino acids; and each P1, which may be the same or different, has one of the following formulas: Xaa1Xaa2His or Xaa1Xaa2His Xaa3 wherein: Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or alpha-hydroxymethylserine; Xaa2 is glycine, alanine, beta-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or alpha-hydroxymethylserine; and Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan. (62) Divided Out of 547077
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