| 摘要 |
THE INVENTION RELATES TO (INDOL-3-YL)-HETEROCYCLE DERIVATIVES HAVING THE GENERAL WHEREIN A REPRESENTS A 5-MEMBERED AROMATIC HETEROCYCLIC RING, WHERSIN X₁, X₂ AND X₃ ARE INDEPENDENTLY SELECTED FROM N, 0, S AND CR; R IS H OR (C₁-₄)ALKYL; OR R, WHEN PRESENT IN X₂ OR X₃, MAY FORM TOGETHER WITH R₃ A 5-8 MEMBERED RING; R₁ IS A 5-8 MEMBERED SATURATED CARBOCYCLIC RING, OPTIONALLY CONTAINING A HETEROATOM SELECTED FROM 0 AND S; R₂ IS H, CH₃ OR CH₂-CH₃ OR R₂ IS JOINED TOGETHER WITH R₇ TO FORM A 6-MEM- BERED RING, OPTIONALLY CONTAINING A HETEROATOM SELECTED FROM 0 AND S, AND WHICH HETEROATOM IS BONDED TO THE 7-POSITION OF THE INDOLE RING; R₃ AND R₄ ARE INDEPENDENTLY H, (C₁-₆)ALKYL OR (C₃-₇)CYCLOALKYL, THE ALKYL GROUPS BEING OPTIONALLY SUBSTITUTED WITH OH, (C1₁-₄)AIKYLOXY, (C₁-₄)ALKYLTHIO, (C₁-₄)ALKYLSULFONYL, CN OR HALOGEN; OR R₃ TOGETHER WITH R₄ AND THE N TO WHICH THEY ARE BONDED FORM A 4-8 MEMBERED RING OPTIONALLY CONTAINING A FURTHER HETEROATOM SELECTED FROM O AND S, AND WHICH IS OPTIONALLY SUB- STITUTED WITH OH, (C₁-₄)ALKYL, (C₁-₄)AIKYLOXY, (C₁-₄)ALKYLOXY- (C₁-₄)ALKYL, OR HALOGEN; OR R₃ TOGETHER
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