发明名称 |
RAGE FUSION PROTEINS AND METHODS OF USE |
摘要 |
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies. |
申请公布号 |
EA012082(B1) |
申请公布日期 |
2009.08.28 |
申请号 |
EA20070000404 |
申请日期 |
2005.08.03 |
申请人 |
TRANSTECH PHARMA, INC. |
发明人 |
MJALLI ADNAN, M.M.;TIAN YE, E.;WEBSTER JEFFREY, C.;ROTHLEIN ROBERT |
分类号 |
C07K14/705;C07K19/00 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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