METHOD FOR PRODUCING FOUNDER ANIMAL FOR REPRODUCING ANIMALS HAVING LETHAL PHENOTYPE CAUSED BY GENE MODIFICATION

摘要

Disclosed is a technique for constantly enabling organ regeneration in order to establish organ regeneration at improved efficiency. It is found out that, in the blastocyst complementation method, a next generation is born by injecting ES cells into the generated blastocysts to thereby complement a defect in an organ such as pancreas, kidney or the like. Further, it is found out that a transgenic animal in which the pancreas or kidney has been thus complemented can transmit the phenotype to the next generation as a founder. Thus, it is clarified that an organ can be regenerated by using such a founder.