B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING
摘要
<p>Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl36H2O to oxidize the D ring and separating the resulting organic layer and drying.</p>
申请公布号
WO2009105210(A2)
申请公布日期
2009.08.27
申请号
WO2009US01030
申请日期
2009.02.19
申请人
HEALTH RESEARCH, INC.;LIU, CHAO;DOBHAL, MAHABEER;POTTER, WILLIAM;MORGAN, JANET;OSEROFF, ALLAN
发明人
LIU, CHAO;DOBHAL, MAHABEER;POTTER, WILLIAM;MORGAN, JANET;OSEROFF, ALLAN