发明名称 |
MODIFICATIONS OF THE HISTONE DEACETYLASE INHIBITOR SUBEROYLANILIDE HYDROXAMIC ACID |
摘要 |
The application relates to compounds of general formula (I) Ar-[CH2]m-Z1-N(Z2-R2)-Z3-[C(O)]r-[CH2]n-Y1-[C(O)]s-Y2-R1, in which the variables can take the values specified in the application. In particularly preferred individual compounds of formula (I), -Z1-N(Z2-R2)-Z3-[C(O)]r- forms an -O-NH-C(O)- or -NH-O-C(O)- group. Said compounds (I) are suitable as medicaments for the treatment of cancer diseases. The effect thereof is due to histone deacetylase inhibition. |
申请公布号 |
WO2008154905(A3) |
申请公布日期 |
2009.08.27 |
申请号 |
WO2008DE00993 |
申请日期 |
2008.06.16 |
申请人 |
SCHEBO BIOTECH AG;SCHEEFERS, HANS;SCHEEFERS-BORCHEL, URSULA |
发明人 |
SCHEEFERS, HANS;SCHEEFERS-BORCHEL, URSULA |
分类号 |
C07D213/64;A61K31/4402;A61P35/00;C07C259/06 |
主分类号 |
C07D213/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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