发明名称 |
NUCLEIC-ACID PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY |
摘要 |
The present invention provides at least one siRNA (small interfering RNA) which inhibits the expression of Mcl-1 within the cell, and which is selected from siRNA having SEQ. ID. NO. 1 sense sequence and SEQ. ID. NO. 2 antisense sequence, siRNA having SEQ. ID. NO. 3 sense sequence and SEQ. ID. NO. 4 antisense sequence, and siRNA having SEQ. ID. NO. 5 sense sequence and SEQ. ID. NO. 6 antisense sequence. The invention also provides a nucleic-acid pharmaceutical composition for cancer therapy comprising the same. The siRNA of the present invention kills cancer cells by inhibiting the expression of Mcl-1 which is commonly expressed in cancer cells by means of RNA-mediated interference (RNAi), and the composition of the present invention can be used as an outstanding anti-cancer preparation. |
申请公布号 |
WO2009104896(A2) |
申请公布日期 |
2009.08.27 |
申请号 |
WO2009KR00762 |
申请日期 |
2009.02.18 |
申请人 |
KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATION FOUNDATION;OH, YU-KYOUNG;SHIM, GAYONG;KIM, SANG-HEE |
发明人 |
OH, YU-KYOUNG;SHIM, GAYONG;KIM, SANG-HEE |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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