发明名称 |
B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES |
摘要 |
The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.
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申请公布号 |
US2009214539(A1) |
申请公布日期 |
2009.08.27 |
申请号 |
US20090437507 |
申请日期 |
2009.05.07 |
申请人 |
TRUBION PHARMACEUTICALS, INC. |
发明人 |
GROSMAIRE LAURA S.;HAYDEN-LEDBETTER MARTHA S.;LEDBETTER JEFFREY A.;THOMPSON PETER A.;SIMON SANDY A.;BRADY WILLIAM |
分类号 |
A61K39/395;C07K16/18 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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