| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to levodop prodrugs, their stereoisomers, enantiomers or pharmaceutically acceptable salts and based on them pharmaceutical composition for ensuring slowed levodop release, as well as to versions of their application and methods of obtaining them, compounds can be applied for treatment or prevention of diseases in which levodop application is indicated. In general formula (I): , Q is selected from X-CO-; X is selected from -O- and -NH-; n equals integer number from 2 to 4; each R1 and R2 is independently selected from hydrogen, -OH, C1-4alkyl and substituted C1-4alkyl, where substituting group is -OH; R3 and R4 represent hydrogen; R5 is selected from hydrogen, C1-4alkyl, phenyl, substituted phenyl, where each substituting group is independently selected from C1-6alcoxy, C1-6alkyl, halogen and -OH; C3-8cycloalkyl, pyridyl, substituted pyridyl, where each substituting group is independently selected from C1-6alkyl and C1-6alcoxy; on condition that formula (I) compound is not a derivative of 1,3-dihexadecanoylpropane-1,2,3-triol. ^ EFFECT: elaboration of pharmaceutical composition for ensuring slowed levodop release. ^ 48 cl, 4 dwg, 32 ex |
