1,3,4-OXADIAZOL-2-ONS AS PPAR-DELTA MODULATORS, BASED ON THEM PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT

摘要

FIELD: chemistry. ^ SUBSTANCE: described are derivatives of 1,3,4-oxadiazol-2-on of formula (I) , where ARYL represents phenyl; Z represents -O(CH2)n- and n represents independent integer number from 1 to 5; X represents S; R1 represents C1-6alkyl; R2 represents phenyl, substituted with C1-6perfluoralkyl; or its pharmaceutically acceptable salt; based on it pharmaceutical composition; and method of disease treatment, where disease can be modulated by activity of PPAR-delta binding. ^ EFFECT: obtaining compounds which possess agonistic or antagonistic activity. ^ 7 cl, 5 ex