| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: described is compound representing 2,5-disubstituted 3-mercaptopentanic acid of formula (I) or its pharmaceutically acceptable salt, where R' represents phenyl, possibly substituted, naphtyl, pyridinyl, 1,2,3,4-tetrahydropyrimidine-2,4-dion-yl, substituted with C1-4alkyl, or tetrahydrothienyl; R2 represents aminopyridinyl, aminothiazolyl or 3-azabicyclo[3.2.1]octyl; R3 represents C1-4alkoxy, possibly substituted with phenyl (substituted with halogen) or pyridinyl; NR5R6 or N-bonded 5- or 6-member heterocyclic ring representing pyrrolidinyl, piperidinyl or piperazinyl ring, non-substituted or monosubstituted, or condensed with benzene ring, which is possibly substituted with C1-4alkoxy; R4 represents N-bonded pyrrolidinyl ring, monosubstituted with C1-4alkyl, which is substituted with NHphenyl; R5 and R6 independently represent hydrogen, C1-4alkyl, possibly substituted, or C2-4alkenyl; and method of obtaining it. ^ EFFECT: obtaining compounds inhibiting carboxypeptidase and which can be used in prevention and treatment of diseases in which inhibiting carboxypeptidase is useful. ^ 7 cl, 1 tbl, 53 ex |
