METHOD OF MAKING HYBRID CELLS THAT EXPRESS USEFUL ANTIBODIES
摘要
This invention relates to a novel hybridoma strategy that uses CD27+ B cells cultured in vitro to induce IgM to IgG class switch prior to fusion with a fusion partner. Hybridomas resulting from the fusion between CD27+ B cells and a fusion partner cell line and antibodies secreted from the hybridomas are included in the invention.
申请公布号
WO2009105150(A2)
申请公布日期
2009.08.27
申请号
WO2009US00562
申请日期
2009.01.28
申请人
THOMAS JEFFERSON UNIVERSITY;DESSAIN, SCOTT, K.;ADEKAR, SHARAD, P.