| 发明名称 |
QUANTITATIVE ASSESSMENT OF INDIVIDUAL CANCER SUSCEPTIBILITY BY MEASURING DNA DAMAGE-INDUCED MRNA IN WHOLE BLOOD |
| 摘要 |
Heparinized human whole blood from patients with invasive breast cancer, with (multiple primary) and without (single primary) a second primary cancer, and from unaffected controls was stimulated with 0.1-10 Gy of radiation and incubated at 37° C. for 2 hours. P21 and PUMA mRNA were then quantified. The results suggest that cancer susceptibility represented by the multiple primary cases was significantly related to over-reaction of p21 mRNA, and not PUMA.
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| 申请公布号 |
US2009215064(A1) |
申请公布日期 |
2009.08.27 |
| 申请号 |
US20090395315 |
申请日期 |
2009.02.27 |
| 申请人 |
HITACHI CHEMICAL CO., LTD.;HITACHI CHEMICAL RESEARCH CENTER, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MITSUHASHI MASATO;ANTON-CULVER HODA;ZIOGAS ARGYRIOS;PEEL DAVID |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
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