2,4-DIAMINOPYRIDINE DERIVATIVES, A PHARMACEUTICAL COMPOSITION AND A MEDICINAL AGENT WHICH ARE BASED THEREON AND USED FOR TREATING OR PREVENTING DISEASES AND DISTURBANCES CAUSED BY THE HYPERACTIVATION OF NMDA-RECEPTORS AND/OR IN THE FORM OF COGNITIVE

摘要

The invention relates to novel 2,4-diaminopyridine derivatives, pharmaceutically acceptable salts and /or solvates thereof, to compositions and medicinal agents containing the novel 2,4-diaminopyridine derivatives and to the use thereof as the NMDA-receptor blockers and cognitive function stimulators. The novel derivatives combine the properties of highly affine NMDA-receptor antagonist with the properties of moderate acetylcholinesterase inhibitors and with the properties of highly affine agonists of nicotine cholinoreceptors and sympathomimetics, whereby determining the comprehensive normalising action thereof on the disballance of several neurotransmitting systems, including glytamatergic, cholinergic and adrenergic systems without undesirable side effects which were previously observed in the known NMDA-antagonists. They not only do not cause the disturbance of intellectual abilities, attention and memory that is typical for the known NMDA-receptor antagonists, but, in addition, can be useful for treating and preventing a range of diseases and disturbances related to disturbed cognitive functions and learning ability. The method for treating or preventing diseases and disorders caused by the incresed activation of the glutamatergic system and/or by the damage of intellectual mnestic functions.