发明名称 |
THROMBIN MUTANT |
摘要 |
A thrombin mutant in which at least serine at position 205 among amino acids in the active center of the thrombin B chain has been replaced with another amino acid, and further at least one of the following replacements have been introduced: (I) replacement of arginine at position 89 in the B-chain with another amino acid; (II) replacement of threonine at position 69 or serine at position 22 in the B-chain with another amino acid; (III) replacement of alanine at position 200 in the B-chain with another amino acid; and (IV) replacement of lysine at position 65 in the B-chain with threonine.
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申请公布号 |
EP2093290(A1) |
申请公布日期 |
2009.08.26 |
申请号 |
EP20070831899 |
申请日期 |
2007.11.15 |
申请人 |
CHISSO CORPORATION;FUJIMORI KOGYO CO., LTD. |
发明人 |
HOSOKAWA, KAZUYA;WADA, TOMOKO |
分类号 |
C12N15/09;A61K38/55;A61P7/02;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/74 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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