PHARMACEUTICAL FORMULATION FOR TREATING CARDIOVASCULAR DISEASE

摘要

A pharmaceutical formulation containing a rosuvastatin and amlodipine is provided to improve the adaptation of patient without side effect by administering in the evening. A pharmaceutical formulation comprises an immediate-release compartment having a rosuvastatin as a pharmacologically active ingredient., its isomer, or its pharmaceutically acceptable, an extended-release compartment having an amlodipine pharmacologically active ingredient, its isomer, or its pharmaceutically acceptable salt. The 80% of rosuvastatin is released in 15 minute after releasing. The amlodipine is releases in two hours after releasing. The extended-release compartment is coated with a coating agent of semi-permeable film.