AIDS VACCINE OR RECOMBINANT ADENOVIRUS FOR TREATING OR PREVENTING AIDS

摘要

A DNA vaccine composition for preventing and treating AIDS (acquired immunodeficiency syndrome) or a recombinant adenovirus are provided to induce broad immune response. A vaccine composition for treating or preventing HIV (Human immunodeficiency virus) comprises an expression vector containing Gag, Env, Pol antigen gene of HIV B type, and conjugated antigen of regulatory protein or recombinant virus vector. Each N terminal of Env, Pol antigen and Reg gene is conjugated with signal sequence of tissue plasminogen activator (tPA). The Pol antigen gene is substituted to phenyulalanine from tyrosine which is 183th amino acid of removing enzyme activation of reverse transcriptase.