发明名称 |
Method of preparing esomeprazole and salts thereof |
摘要 |
Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(−)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(−)-binol, and removing the (S)-(−)-binol moiety from the crystallized inclusion complex. |
申请公布号 |
ZA200801854(B) |
申请公布日期 |
2009.08.26 |
申请号 |
ZA20080001854 |
申请日期 |
2006.07.11 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
HA, TAE HEE;KIM, WON JEONG;OH, HEE SOOK;PARK, CHANG HEE;LEE, JAE CHUL;KIM, HAN KYONG;SUH, KWEE-HYUN |
分类号 |
A61P;C07D |
主分类号 |
A61P |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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