| 摘要 |
<p>The present invention discloses prodrugs of chloramphenicol, thiamphenicol and their analogs, as well as pharmaceutically acceptable salts thereof, including nitrogen-containing esters of both alcohol groups. These prodrugs have the Formula (I), in which R, Aa, Ll, Mm, Xx, Y and R3 are as defined in the claims. In certain embodiments these prodrugs are sufficiently water-soluble to serve the functions needed of a prodrug of chloramphenicol, thiamphenicol and their analogs. In one embodiment, a certain subclass of the compounds also possess the hydrolytic stability needed to maintain the prodrug in solution in the subject's system until appropriate conditions exist when the prodrug can hydrolyze, releasing the active compound in question.</p> |
