发明名称 HYSTONE DESACETYLASE INHIBITORS FROM NOVEL BENZAMIDE DERIVATIVES WITH STRONG DIFFERENTIAL ANTI-PROLOFERATIVE ACTIVITY
摘要 FIELD: chemistry. ^ SUBSTANCE: claimed invention relates to formula I compounds and their pharmaceutically acceptable salts. Compounds of claimed invention can be applied as medication for treating disorders induced by cell proliferation or mediated by nucleus receptors. In general formula , A represents phenyl or unsaturated monocyclic 6-member group, containing nitrogen atom as heteroatom; B represents phenyl group; Z represents bond; Y represents group -CO-NH-CH2-; R1, R2, R3 independently represent hydrogen; R4 represents aminogroup; and one of X1, X2 , X3 or X4 represents halogen atom, while other ones of X1, X2, X3 or X4 independently represent hydrogen atom. ^ EFFECT: invention also relates to method of obtaining, pharmaceutical compositions, to application of invention compounds, as well as to formula IV compound. ^ 22 cl, 1 dwg, 2 tbl, 7 ex
申请公布号 RU2364589(C2) 申请公布日期 2009.08.20
申请号 RU20050128550 申请日期 2004.02.09
申请人 SHEHN'CHZHEHN' CHIPSKRIN BAJOSAJENSIZ LTD. 发明人 LU SJAN'-PIN;LI CHZHIBIN';SE AJKHUA;LI BOJUJ;NIN CHZHITSJAN;SHAN' SUN;DEHN TO;KHU VEHJMIN
分类号 A61K;A61K31/165;A61K31/277;A61K31/44;A61K31/4406;A61P17/06;A61P35/00;C07C233/51;C07C237/40;C07C237/42;C07D213/56 主分类号 A61K
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