| 发明名称 |
Duplex Oligonucleotides with Enhanced Functionality in Gene Regulation |
| 摘要 |
Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which contain modified nucleotides and mismatches between the two strands of the molecule at specific nucleotide positions.
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| 申请公布号 |
US2009209626(A1) |
申请公布日期 |
2009.08.20 |
| 申请号 |
US20090368856 |
申请日期 |
2009.02.10 |
| 申请人 |
DHARMACON, INC. |
发明人 |
KHVOROVA ANASTASIA;LEAKE DEVIN;ROBERTSON BARBARA;VERMEULEN ANNALEEN;YAMADA CHRISTINA |
| 分类号 |
A61K31/7105;A61K48/00;C07H21/02;C12N5/00 |
主分类号 |
A61K31/7105 |
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