发明名称 |
Mutations of the pik3ca gene in human cancers |
摘要 |
Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the P13K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target. |
申请公布号 |
US2009208505(A1) |
申请公布日期 |
2009.08.20 |
申请号 |
US20050591347 |
申请日期 |
2005.02.18 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
SAMUELS YARDENA;VELCULESCU VICTOR;KINZLER KENNETH;VOGELSTEIN BERT |
分类号 |
A61K39/395;A61K31/352;A61K31/5377;A61K31/7052;A61P35/00;C07H21/00;C12Q1/48;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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