发明名称 |
NON-HUMAN MAMMAL MODEL OF EPILEPSY |
摘要 |
<p>Provided is a genuine model animal of epilepsy, since most of the existing model animals are so-called seizure model animals showing forcibly-induced seizure. Also provided is a method whereby a recombinant can be easily distinguished. A non-human mammal model of epilepsy which is an epilepsy model of a non-human animal such as rat having the same genetic defect as human genetic defect causing epilepsy, which carries a genetic mutation that is the genetic defect having been transferred into the non-human mammal DNA of neuron nicotinic acetylcholine receptor a4 subunit (CHRNA4) gene or ß2 subunit (CHRNB2) gene relating to human autosomal dominant nocturnal frontal lobe epilepsy and which also carries a mutated gene obtained by transferring a specific probe thereinto. A recombinant of this non-human mammal model of epilepsy can be easily distinguished.</p> |
申请公布号 |
WO2009101939(A1) |
申请公布日期 |
2009.08.20 |
申请号 |
WO2009JP52230 |
申请日期 |
2009.02.10 |
申请人 |
FUKUOKA UNIVERSITY;HIROSAKI UNIVERSITY;HIROSE, SHINICHI;KANEKO, SUNAO |
发明人 |
HIROSE, SHINICHI;KANEKO, SUNAO |
分类号 |
C12N15/09;A01K67/02;A01K67/027;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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