CELLULAR SCREENING ASSAY FOR MODULATORS OF MEVALONATE PATHWAY

摘要

The present invention relates to a cellular assay for screening modulators of the mevalonate pathway. More specifically the cellular assay comprises the following steps: a. culturing eukaryotic cells expressing a protein with a prenylation signal in the presence and in the absence of a test compound; and, b. comparing the subcellular localization of said protein with a prenylation signal in the presence of a test compound with said subcellular localization in the absence of the test compound; wherein a change in the subcellular localization of said protein with a prenylation signal is indicative that said test compound is a modulator of the mevalonate pathway.