发明名称 |
Inhibitor of Endogenous Human Interferon-Gamma |
摘要 |
The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-gamma) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-gamma with preserved affinity to the hIFN-gamma receptor. The derivatives represent genetically modified variants of hIFN-gamma where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-gamma inactivated by physical or chemical methods.
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申请公布号 |
US2009208452(A1) |
申请公布日期 |
2009.08.20 |
申请号 |
US20050886853 |
申请日期 |
2005.10.05 |
申请人 |
IVANOV IVAN;TSANEV RUMEN;NACHEVA GENOVEVA;GRIGOLEIT HANS-GUENTHER;GUNTHER ROLF |
发明人 |
IVANOV IVAN;TSANEV RUMEN;NACHEVA GENOVEVA;GRIGOLEIT HANS-GUENTHER;GUNTHER ROLF |
分类号 |
A61K38/21;C07K14/57 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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地址 |
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