CO-CONTINUOUS HYBRID STRUCTURE FOR THE REGENERATION OF BONE DEFECTS

摘要

The invention relates to a method for obtaining a scaffold consisting of a porous PCL matrix and a hydroxyapatite coating, comprising the following steps: (i) preparing a homogeneous PCL solution in a mixture of two solvents, namely a PCL solvent and a PCL nonsolvent; (ii) filling a mould with the homogeneous solution; (iii) cooling the homogeneous solution to a temperature lower than the temperature at which the separation of the two liquid phases occurs; (iv) isothermal treatment; (v) solidifying both phases, reducing the temperature; (vi) extracting the PCL solvent and the PCL nonsolvent, together with a third solvent; and (vii) depositing biomimetic HAp. The structure is suitable for use in tissue engineering.