| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: claimed invention relates to compounds of formula (I): , where: R1 represents hydrogen atom, (C1-C4)-alkyl, group -(CH2)mOH, group -(CH2)mCN, group -(CH2)mNR9R10; R2 represents hydrogen atom or (C1-C4)-alkyl; R3 represents phenyl, substituted with radicals R6, R7, R8; R4 represents: group ; heterocyclic radical selected from radicals: ; ; ; R5 represents hydrogen atom or (C1-C4)-alkyl; R6, R7 and R8 represent independently on each other hydrogen atom, halogen atom, (C1-C4)-alkyl, (C1-C4)-alkoxy, hydroxyl, cyanogroup, group -(CH2)nNR9R10, group -O-(CH2)mNR9R10; R9 and R10 represent independently on each other hydrogen atom or (C1-C4)-alkyl; or R9 and R10 together with nitrogen atom, to which they are bonded, form heterocyclic radical, selected from pyrrolidin-1-yl, pyperidin-1-yl, morpholin-4-yl or pyperasin-1-yl, substituted or non-substituted in position 4 with (C1-C4)-alkyl; R11 represents hydrogen atom or (C1-C4)-alkyl; R12 represents hydrogen atom, (C1-C4)-alkyl, group -(CH2)m-CO-R16; R13 represents hydrogen atom, (C1-C4)-alkyl, phenyl, group NR17R18, group ; R14 represents hydrogen atom, (C1-C4)-alkyl, group -NR17R18; R15 represents hydrogen atom, (C1-C4)-alkyl, group -NR19R20, -COO(C1-C4)-alkyl; R16 represents hydroxyl, (C1-C4)-alkoxy, group -NR9R10; R17 and R18 represent independently on each other hydrogen atom or (C1-C4)-alkyl; R18 can also represent group -COR21, group -SO2R22; R19 and R20 represent independently on each other hydrogen atom or (C1-C4)-alkyl; R20 can also represent (C3-C6)-cycloalkyl, (C3-C6)-cycloalkylmethyl, group -(CH2)mNR9R10; R21 represents (C1-C4)-alkyl, (C3-C6)-Cycloalkyl, group -(CH2)mNR9R10; R22 represents (C1-C4)-alkyl; m equals 1, 2 or 3; n equals 1, 2 or 3. As well as to medication and pharmaceutical composition, to method of obtaining it and its application in therapy. ^ EFFECT: obtained and described are novel compounds which can be useful in medicine. ^ 14 cl, 67 ex, 3 tbl |
