发明名称 |
METHOD OF CLOPIDOGREL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY |
摘要 |
FIELD: medicine. ^ SUBSTANCE: invention concerns medicine, particularly experimental cardiology and pharmacology, and can be used for correction of endothelial dysfunction that is ensured by simulation of endothelial dysfunction in experiment by daily intraperitoneal introduction to Wistar male rats of N-nitro-L-arginine methyl ester in a dose 25 mg/kg, within 7 days. Correction of dysfunction is carried out daily within 7 days by intragastric introduction of Clopidogrel in a dose 6.5 mg/kg. Degree of dysfunction development is determined by relation of endothelium-independent to endothelium-dependent vasodilation. ^ EFFECT: method provides correction of endothelial dysfunction in specific simulation environment. ^ 2 tbl |
申请公布号 |
RU2364394(C1) |
申请公布日期 |
2009.08.20 |
申请号 |
RU20080110103 |
申请日期 |
2008.03.19 |
申请人 |
POKROVSKIJ MIKHAIL VLADIMIROVICH;POKROVSKAJA TAT'JANA GRIGOR'EVNA;ARTJUSHKOVA ELENA BORISOVNA;TSEPELEV VASILIJ JUR'EVICH |
发明人 |
POKROVSKIJ MIKHAIL VLADIMIROVICH;POKROVSKAJA TAT'JANA GRIGOR'EVNA;ARTJUSHKOVA ELENA BORISOVNA;TSEPELEV VASILIJ JUR'EVICH;BELOUS ALEKSANDR SERGEEVICH;KOROKIN MIKHAIL VIKTOROVICH;GUDYREV OLEG SERGEEVICH;GLADCHENKO MIKHAIL PETROVICH;GUREEV VLADIMIR VLADIMIROVICH;BABKO ANNA VLADIMIROVNA;NOVIKOV OLEG OLEGOVICH;NOVIKOVA MARINA JUR'EVNA;KOCHKAROV VLADIMIR ISKHAKOVICH;DANILENKO LJUDMILA MIKHAJLOVNA;TSYBUL'SKIJ IGOR' VALER'EVICH;KHARDIKOVA ELENA MIKHAJLOVNA;LUCHKINA ELENA VADIMOVNA;ERSHOV IL'JA NIKOLAEVICH |
分类号 |
A61K31/198;A61K31/4365;A61P9/00 |
主分类号 |
A61K31/198 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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