INHIBITORS OF KINASE ACTIVITY WITH 1,2-DI-CYCLYL SUBSTITUTED ALKYNE STRUCTURES

摘要

This invention relates to compounds that inhibit protein kinase activity. More particularly, the invention relates to compounds, compositions, and methods fo inhibiting Ret receptor kinase activity, c-Raf kinase activity and/or VEGF receptor kinase activity. These compounds are alkynes substituted by carbocyclic or heterocyclic rings at both ends with further substitutions thereon. They further show in vivo activity against solid tumor disease models.