| 摘要 |
A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, -CN, -C(Rc)2OH, -N(Rd)C(-X)Rc, -C(-X)N(Rc)(Rd), -S(O)m-Rc, -N(Rc)(Rd)S(O)2, -S(O)2N(Rc)(Rd), -N(Rc)2, aryl optionally substituted with Ra or -O-aryl optionally substituted with Ra; or B is present and is -(CH2)n-, -C(Rb)2- or -O-, or B taken together with A or Z can be -C-C(Rb)-, -C(Rb)-C-, -CH2-CH(Rb)- or -CH(Rb)-CH2-; D is -O- or -S(O)m'-; E is a bond or is -(CH2)n-, -N(Rd)-, -(CH2)nN(Rd)- or -N(Rd)(CH2)n-; F is -C(-X)-; G is -(CH2)n-, -N(Rd)-, -(CH2)nN(Rd)- or -N(Rd)(CH2)n; J is a bond, -O-, -N(RC)C(-X)-, -C(-X)N(Rc)-, -S(O)m'-, -N(Rc)S(O)m-, -S(O)nN(Rc)-, -N(Rc)- or -N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.
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