| 摘要 |
The invention relates to the fields of immunology and molecular medicine. In particular, it relates to protein complexes that can be applied as therapeutic agent to induce apoptotic cell death in a target cell population, for example tumour cells or virally infected cells. Provided is a multivalent monospecific protein complex comprising at least six polypeptides capable of recognizing and binding to a specific Major Histocompatibility Complex (MHC)-peptide complex, which complex induces apoptosis through the recognition of and binding to MHC-peptide molecules of a target cell. Also provided is the therapeutic use of a protein complex, for example for the manufacture of a medicament for the treatment of cancer, a viral or a microbial infection.
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