发明名称 |
METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF RTK INHIBITORS |
摘要 |
<p>This invention relates to methods for treating, preventing and/or managing cancer in a subject including enhacing the efficacy of a Receptor Tyrosine Kinase inhibitor (e.g., a small molecule RTK inhibitor, e.g., Sorafenib or Erlotinib) by administering to the subject a Vascular Disrupting Agent (e.g., a Combretastatin or derivative thereof) sequentially or simultaneously in combination with said RTK inhibitor. Pharmaceutical compositions comprising a combination of a RTK inhibitor and a VDA are also provided.</p> |
申请公布号 |
WO2009103076(A1) |
申请公布日期 |
2009.08.20 |
申请号 |
WO2009US34318 |
申请日期 |
2009.02.17 |
申请人 |
OXIGENE, INC.;CHAPLIN, DAVID, J.;SIIM, BRONWYN, G. |
发明人 |
CHAPLIN, DAVID, J.;SIIM, BRONWYN, G. |
分类号 |
A61K31/4412;A61K31/517;A61K31/66;A61K31/661;A61P35/00 |
主分类号 |
A61K31/4412 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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