发明名称 |
SUSTAINED RELEASE PREPARATION |
摘要 |
<p>Disclosed is a sustained-release preparation which is prepared by shaping a granule comprising a blood coagulation factor Xa inhibitor and a mixture of at least two hydrophilic polymers. Also disclosed is a pharmaceutical composition comprising a combination of the sustained-release preparation and an immediate release preparation comprising a blood coagulation factor Xa inhibitor. It becomes possible to provide a controlled release preparation comprising a blood coagulation factor Xa inhibitor for the prevention or treatment of thrombosis, which can control the activity of blood coagulation factor Xa for a long term and is excellent in convenience and compliance. It is also becomes possible to provide a method for producing the controlled release preparation.</p> |
申请公布号 |
EP2090300(A1) |
申请公布日期 |
2009.08.19 |
申请号 |
EP20070832746 |
申请日期 |
2007.11.29 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
IINUMA, SATOSHI;YOSHINARI, TOMOHIRO;TOTTORI, TSUNEAKI |
分类号 |
A61K9/22;A61K31/506;A61K47/10;A61K47/38;A61P7/02;A61P9/10 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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