发明名称 |
CRIPTO-ANTAGONISMUS VON ACTIVIN UND TGF-B SIGNALISIERUNG |
摘要 |
Cripto, a developmental oncoprotein, antagonizes activin and TGF-² signaling by forming a complex with activin and TGF-² and their type II receptors. This complex precludes the formation of a functional activin/TGF-²€¢type II€¢type I complex, thereby blocking the signaling of activin and TGF-². Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-² complex may enhance antiproliferative effects of activin and TGF-². |
申请公布号 |
AT437950(T) |
申请公布日期 |
2009.08.15 |
申请号 |
AT20040783979T |
申请日期 |
2004.09.14 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
VALE, WYLIE;GRAY, PETER;HARRISON, CRAIG |
分类号 |
C12N15/12;A61K38/17;A61K39/395;C07D;C07K14/47;C07K14/71;C07K14/82;C07K16/22 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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