| 摘要 |
The present disclosure is directed to a process for the chemical syn-thesis of (-)-.DELTA.9- ^tetrahydrocannabinol (.DELTA.9--THC) and related compounds of formula (I). In particular, the process comprises a one-pot condensation and sulfonylatton re-action sequence that produces crude .DELTA.9--THC aryl sulfonate or related compounds. Sulfo.pi.ylatio.pi. of .DELTA.9-THC or related com-pounds immediately upon their formation imparts stability to the cannabinoids, and prevents formation of the corresponding .DELTA.8 isomer. .DELTA.9THC aryl sulfonates may be readily separated from A6THC aryl sul-fonates using reverse phase chromatogra-phy. Hydrolysis of the .DELTA.9-THC aryl sul-fonates or related compounds produces .DELTA.9--THC or related compounds containing rel-atively low amounts of the corresponding .DELTA.8 isomer. (Formula I).
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