发明名称 CHIRAL ARYLKETONES IN THE TREATMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DISEASES
摘要 The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.
申请公布号 US2009203652(A1) 申请公布日期 2009.08.13
申请号 US20080327767 申请日期 2008.12.03
申请人 DOMPE PHA.R.MA S.P.A. 发明人 ALLEGRETTI MARCELLO;BERTINI RICCARDO;BIZZARRI CINZIA;CESTA MARIA CANDIDA;COLOTTA FRANCESCO
分类号 A61K31/12;A61K31/10;A61K31/192;A61K31/222;A61K31/44;A61K31/662;A61P29/00;C07C45/56;C07C45/67;C07C49/213;C07C49/215;C07C49/782;C07C49/784;C07C69/612;C07C69/738;C07C69/78;C07C271/18;C07C309/65;C07C311/21;C07C317/06;C07C317/24;C07D209/46;C07D213/50;C07D319/06;C07F9/40 主分类号 A61K31/12
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