IMPROVED STATIN PRODUCTION

摘要

The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin and/or simvastatin comprising culturing a mutant host capable of producing said compound wherein esterase activity in said mutant host is more than 25% below the activity of said esterase in the parent host. Also, the present invention provides mutant hosts having 2-methylbutyric esterase and/or 2,2-dimethylbutyric esterase activity which is more than 25% below the activity of said esterase in the parent host.