发明名称 |
ANTIFUNGAL FORMULATION AND METHOD OF PREPARATION |
摘要 |
A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-1 13 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the buffer molarity of the pharmaceutical preparation is suitable to achieve greater than 99% killing of C. albicans in vitro. A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-113 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the pharmaceutical preparation has a buffer molarity of about 25 mM or less. A method for treating a microbial infection such as a fungal or bacterial infection in an individual comprises administering to the individual a therapeutically effective amount of a preparation comprising a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-113 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the buffer molarity of the preparation is suitable to achieve greater than 99% killing of C. albicans in vitro. A method for treating a microbial infection such as a fungal or bacterial infection in an individual comprises administering to the individual a therapeutically effective amount of a preparation comprising a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-113 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the preparation has a buffer molarity of about 25 mM or less. |
申请公布号 |
WO2009005798(A3) |
申请公布日期 |
2009.08.13 |
申请号 |
WO2008US08179 |
申请日期 |
2008.07.01 |
申请人 |
PACGEN BIOPHARMACEUTICALS CORPORATION;TRUSTEES OF BOSTON UNIVERSITY;CHENG, DAVID, J.;OPPENHEIM, FRANK, G.;HELMERHORST, EVA, J. |
发明人 |
CHENG, DAVID, J.;OPPENHEIM, FRANK, G.;HELMERHORST, EVA, J. |
分类号 |
A61P31/10;A61K9/08;A61K38/04;A61P31/04;A61Q11/00 |
主分类号 |
A61P31/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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