发明名称 |
PROCESS FOR THE PREPARATION OF DIBENZO [B,D]AZEPIN-6-ONE DERIVATIVE |
摘要 |
The invention relates to a process for the optical resolution of a dibenzo[b,d]azepinone derivative of the formula (II) wherein R1 is hydrogen or halogen and R2 has the meaning of C1- 4-alkyl optionally substituted with C3-7-cycloalkyl or benzyl which is optionally substituted with C1-4-alkoxy to obtain a (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one of the formula (I) wherein R1 is as above. The (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-ones of formula (I) can be used as chiral building blocks for the preparation of malonamide derivatives which have the potential to act as ?-secretase inhibitors and therefore may be useful in the treatment of Alzheimer's disease and cancer. |
申请公布号 |
WO2008145525(A3) |
申请公布日期 |
2009.08.13 |
申请号 |
WO2008EP55937 |
申请日期 |
2008.05.15 |
申请人 |
F. HOFFMANN-LA ROCHE AG;HOFFMANN-EMERY, FABIENNE;JAKOB-ROETNE, ROLAND |
发明人 |
HOFFMANN-EMERY, FABIENNE;JAKOB-ROETNE, ROLAND |
分类号 |
C07D225/08 |
主分类号 |
C07D225/08 |
代理机构 |
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