PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF

摘要

Compounds represented by formula (I) or (II) against cell releasing TNF alpha, their pharmaceutically acceptable salts or hydrates and preparation methods and uses thereof, in which A and B represent CH2, CO, SO, SO2 respectively; D represents S, NH, NC1-6 alkyl; R1 represents H, one-two same or different radical(s) selected from the group consisting of F, Cl, Br, C1-4 alkyl,OH,OC1-4 alkyl,NO2,NHC(O)C1-4 alkyl,NH2,NH(C1-4 alkyl),N(C1-4 alkyl)2. ® KIPO & WIPO 2009