发明名称 |
ANTIBODY-DRUG CONJUGATES AND METHODS |
摘要 |
The present invention relates to antibody-drug conjugate compounds of Formula I: <?in-line-formulae description="In-line Formulae" end="lead"?>Ab-(L-D)p I<?in-line-formulae description="In-line Formulae" end="tail"?> where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.
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申请公布号 |
US2009202536(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
US20080326721 |
申请日期 |
2008.12.02 |
申请人 |
GENENTECH, INC. |
发明人 |
EBENS, JR. ALLEN J.;JACOBSON FREDERIC S.;POLAKIS PAUL;SCHWALL RALPH H.;SLIWKOWSKI MARK X.;SPENCER SUSAN D. |
分类号 |
A61K39/395;A61K47/48;A61P35/00;C07D491/14;C07D498/18;C07K16/00;C07K16/10;C07K16/28;C07K16/30;C07K16/32;C07K16/46;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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