BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID
摘要
The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety.
申请公布号
WO2009099672(A2)
申请公布日期
2009.08.13
申请号
WO2009US00813
申请日期
2009.02.07
申请人
THE SCRIPPS RESEARCH INSTITUTE;GRUNEWALD, JAN;TSAO, MENG-LIN;PERERA, ROSHAN;LERNER, RICHARD, A.;SMIDER, VAUGHN, V.;SCHULTZ, PETER, G.
发明人
GRUNEWALD, JAN;TSAO, MENG-LIN;PERERA, ROSHAN;LERNER, RICHARD, A.;SMIDER, VAUGHN, V.;SCHULTZ, PETER, G.