摘要 |
<p>The invention relates to methods for the treatment of cardiac diseases associated with fibrosis, in particular, chronic cardiac failure or hypertensive heart disease by the use of compounds which are capable of decreasing the activity of the Procollagen C-Proteinase or PCP. The invention also relates to methods for the developing a personalized therapy for the treatment of a patient suffering from a cardiac disease associated to myocardial fibrosis comprising determine in a sample from said patient a parameter indicative of the PCP activity and if the value of said parameter is higher than a predefined threshold value, then the patient is candidate to the treatment with a therapeutically effective amount of a PCP inhibitory agent, in particular, with torasemide.</p> |
申请人 |
PROYECTO DE BIOMEDICINA CIMA, S.L.;LOPEZ SALAZAR, BEGONA;GONZALEZ MIQUEO, ARANTXA;DIEZ MARTINEZ, DOMINGO FRANCISCO JAVIER |
发明人 |
LOPEZ SALAZAR, BEGONA;GONZALEZ MIQUEO, ARANTXA;DIEZ MARTINEZ, DOMINGO FRANCISCO JAVIER |