METHODS FOR PREVENTING OR TREATING INSULIN RESISTANCE
摘要
The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r + 1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt + 1, except that when a is 1, pt may also be 1.
申请公布号
WO2009100363(A2)
申请公布日期
2009.08.13
申请号
WO2009US33440
申请日期
2009.02.06
申请人
CORNELL UNIVERSITY;EAST CAROLINA UNIVERSITY;NEUFER, P. DARRELL;ANDERSON, ETHAN, J.;SZETO, HAZEL, H.
发明人
NEUFER, P. DARRELL;ANDERSON, ETHAN, J.;SZETO, HAZEL, H.