发明名称 |
2-AMINOPYRIDINE KINASE INHIBITORS |
摘要 |
<p>2-Aminopyridine compounds having the structure of Formula I, and pharmaceutically acceptable salts of these compounds. Compounds of Formula I inhibit the activity of tyrosine kinase enzymes in animals, including humans, and are useful in the treatment and/or prevention of various diseases and conditions. In particular, compounds disclosed herein are inhibitors of kinases, in particular, but not limited to, KDR, Tie-2, F1t3, FGFR3, Ab1, Aurora A, c-Src, IGF- IR, ALK, c-MET, RON, PAK1, PAK2, and TAK1, and can be used in the treatment of proliferative diseases, such as, but not limited to, cancer. The present invention is also directed to a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention is further directed to a method of treating a patient having a condition which is mediated by protein kinase activity by administering to the patient a therapeutically effective amount of the above-mentioned pharmaceutical composition.</p> |
申请公布号 |
WO2009099982(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
WO2009US32791 |
申请日期 |
2009.02.02 |
申请人 |
OSI PHARMACEUTICALS, INC.;STEINIG, ARNO, G.;MULVIHILL, MARK, J.;WANG, JING;WERNER, DOUGLAS, S.;WENG, QINGHUA;KAN, JULIE;COATE, HEATHER;CHEN, XIN |
发明人 |
STEINIG, ARNO, G.;MULVIHILL, MARK, J.;WANG, JING;WERNER, DOUGLAS, S.;WENG, QINGHUA;KAN, JULIE;COATE, HEATHER;CHEN, XIN |
分类号 |
A61K31/4427;A61P35/00;C07D401/04;C07D401/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04;C07D487/04;C07D491/04;C07D495/04;C07D498/04;C07D513/04 |
主分类号 |
A61K31/4427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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