3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONE AS CXC-CHEMOKINE RECEPTOR LIGAND

摘要

PROBLEM TO BE SOLVED: To provide a compound controlling activity of the CXC chemokine receptor. SOLUTION: There is disclosed a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof which is useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer. There is also provided a pharmaceutical composition comprising the compound represented by formula (I) in combination with a pharmaceutically acceptable carrier or diluent or both. Further a method is provided for treatingα-chemokine-mediated diseases in mammal. The method comprises a step of administering an effective amount of compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof to a patient in need of such treatment. COPYRIGHT: (C)2009,JPO&INPIT