PROCESS FOR THE PREPARATION OF (-) -DELTA 9-TETRAHYDROCANNABINOL

摘要

The present disclosure is directed to a process for the chemical synthesis of (-)-?9- ^tetrahydrocannabinol (?9-THC) and related compounds of formula (I). In particular, the process comprises a one-pot condensation and sulfonylatton reaction sequence that produces crude ?9-THC aryl sulfonate or related compounds. Sulfopylatiop of ?9-THC or related compounds immediately upon their formation imparts stability to the cannabinoids, and prevents formation of the corresponding ?8 isomer. ?9THC aryl sulfonates may be readily separated from A6THC aryl sulfonates using reverse phase chromatography. Hydrolysis of the ?9-THC aryl sulfonates or related compounds produces ?9-THC or related compounds containing relatively low amounts of the corresponding ?8 isomer. (Formula I).