发明名称 |
NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF DENGUE VIRUS |
摘要 |
An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal. |
申请公布号 |
CA2708668(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
CA20092708668 |
申请日期 |
2009.01.12 |
申请人 |
VGX PHARMACEUTICALS, LLC |
发明人 |
RAMANATHAN, MATHURA P.;SARDESAL, NIRANJAN Y. |
分类号 |
A61K31/70;A61K39/295;C12N7/01;C12P19/34 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|