| 摘要 |
The present invention relates to methods for correlating histology and enzymatic activity of a biological sample, the method comprising the steps of: (i) providing a cryopreserved biological sample, wherein said sample comprises a series of consecutively sliced sections; (ii) obtaining histological data of a first subset of said series of sections; (iii) lysing a second subset of sections of said series of sections to obtain a lysate wherein specific enzyme activities are preserved; (iv) assaying the lysate of step (iii) for enzymatic reaction with one or more substrates; and (v) correlating the histology and enzymatic activity of the biological sample.
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